Tac has previously been noted as an effective
Tacrolimus concentrations in whole blood samples can be determined using immunoassays or liquid chromatography–tandem mass spectrometry (LC-MS/MS)
Tac administration requires
Tacrolimus assay standardization, which must include all facets of the
KT recipients on stable doses of BID TAC and had C trough between 5 to 7 ng/mL 14,15,28,29 were admitted to the Chulalongkorn
We chose warfarin, tacrolimus, digoxin and levetiracetam as candidates for the following reasons: (1) close monitoring of warfarin through prothrombin time and
Keywords: tacrolimus immunosuppression, trough concentration, abbreviated AUC, biopsy-proven acute rejection, therapeutic drug monitoring Introduction Tacrolimus (TAC) is a potent calcineurin inhibitor which has been shown to be efficacious in prophylaxis of renal allograft rejection
1 For years, clinicians had been following guidelines published in 2009, which were heavily reliant on monitoring the patient’s Tacrolimus trough level
Tacrolimus
Of 155 tacrolimus measurements, only 48
1,4,5 Although, plasma tacrolimus concentrations have been measured and an equivalent therapeutic range in this matrix suggested (0
After initial dosing, and for maintenance treatment, tacrolimus doses should be adjusted according to whole-blood tacrolimus trough concentration (especially during episodes of diarrhoea)
A multivariable Cox regression model confirmed that high tacrolimus IPV was an independent risk factor for graft failure in the high risk group (HR, 2
The frequency of tacrolimus concentration measurements in the entire cohort was 6
3% and 20
Monitoring the blood concentration is important if certain drugs are given with tacrolimus
Measurement of tacrolimus from blood collected on a microsampling device can be successfully automated with a Gerstel MPS robot
60 to 0
50) [9 Objectives: This quality improvement project sought to determine if clinical pharmacist office visits, or consults, had an impact on therapeutic tacrolimus levels in patients after kidney transplant through analysis of tacrolimus serum concentrations before versus after a pharmacist visit
The initial dose of tacrolimus is typically calculated in proportion to total body weight, with subsequent doses adjusted on the basis of whole